We are currently developing the RAMANBIOASSAY together with our scientific project partner, the Leibniz Institute for Photonic Technologies e.V. (Leibniz IPHT) das RAMANBIOASSAY. This is an innovative analysis concept for the rapid and reliable determination of pathogenic bacteria from patient samples, based on Raman spectroscopy.
Antibiotic-resistant microorganisms are the greatest threats to the healthcare system worldwide. Their therapy is complex and costly. The right therapy decision is life-saving.
As an integrated platform for selecting the right antibiotic within minutes and with short diagnostic times, our RAMANBIOASSAY represents an efficient solution approach. With the RAMANBIOASSAY, results on antibiotic resistance and minimum inhibitory concentration (MIC) can be obtained from blood and urine samples within only 3.5 hours, with minimal personnel input and in a highly standardised manner.
The test is carried out in the following steps:
- The standardised inoculum is placed in a ready-to-use and cost-efficient chip.
- The reaction of the microorganisms to the antibiotics applied to the chip at different concentrations is recorded.
- In less than 3.5 hours, the resistogram is issued.
Our clinical diagnostics is based on the interaction of organic material with photons and enables bioparticles to be easily detected and determined, e.g. in blood, urine, air and water.
Advantages in sample, diagnosis and costs
- Easy standardised and automated sample preparation
- Low staff involvement and training requirements
- Results in less than 3.5 hours
- Rapid diagnostics for targeted and tailored therapy
- Inexpensive disposable chip system requires no reagent preparation
- Low sample costs
- Minimal manual steps
- Low possibility of errors
- Sample identification through RFID
- Maximum transparency and traceability
- Connection to the laboratory information management system (LIMS)
- Increased efficiency and minimisation of errors
Faster and cheaper diagnosis
The specific biophotonic signature of a bacterium, depending on the antibiotic concentration, is used as a highly sensitive parameter to determine antibiotic resistance and the minimum inhibitory concentration (MIC) in only a short time. In combination with the culture independence of the RAMANBIOASSAY, the analysis time can be reduced to approx. 2 to 3.5 hours from sample collection to result. This enables targeted therapy at an early stage of treatment and the use of broad-spectrum antibiotics can be avoided. In addition, the innovative chip concept can significantly reduce diagnostic costs compared to conventional methods.
The RamanBioAssay from Biophotonics Diagnostics thus combines the advantages of a rapid and precise pathogen determination on both a qualitative and quantitative level with a considerable reduction in the duration of diagnosis and a significant reduction in costs.
